1. Analyses have been made of the electrolytes and proteins of serum and transudates from human subjects.

2. The distribution ratios of HCO3, Cl, Na, and H+ deviated from unity as predicted by the Gibbs-Donnan law for similar heterogeneous systems.

3. Analyses of serum, and of artificial salt solutions approximating edema fluid in composition, after equilibration across collodion membranes showed distributions similar to those between serum and edema fluid in vivo.

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