A new technique is proposed for computing the active state of striated muscle, based on the three component model of Fenn and Marsh (8) and of Hill (7). The method permits calculation of the time course of the active state from its peak to the time at which maximum isometric twitch tension is reached. The intormation required for the calculation can be obtained from a single muscle without moving it from its mount in the lever system. The time course of the active state proved to be a function of the length of the muscle. This length dependency led to the predictions that (a) the length at which maximum force is developed during tetanic stimulation is different from that at which it is developed during a twitch, and (b) the tetanus-twitch tension ratio is a function of length. Both predictions were verified in a series of experiments on the rat gracilis anticus muscle at 17.5°C.
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1 October 1967
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October 01 1967
The Active State of Mammalian Skeletal Muscle
Alan S. Bahler,
Alan S. Bahler
From the Departments of Biomedical Engineering, Environmental Medicine, and Medicine, The Johns Hopkins University and Hospital, Baltimore, Maryland 21205.
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John T. Fales,
John T. Fales
From the Departments of Biomedical Engineering, Environmental Medicine, and Medicine, The Johns Hopkins University and Hospital, Baltimore, Maryland 21205.
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Kenneth L. Zierler
Kenneth L. Zierler
From the Departments of Biomedical Engineering, Environmental Medicine, and Medicine, The Johns Hopkins University and Hospital, Baltimore, Maryland 21205.
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Alan S. Bahler
From the Departments of Biomedical Engineering, Environmental Medicine, and Medicine, The Johns Hopkins University and Hospital, Baltimore, Maryland 21205.
John T. Fales
From the Departments of Biomedical Engineering, Environmental Medicine, and Medicine, The Johns Hopkins University and Hospital, Baltimore, Maryland 21205.
Kenneth L. Zierler
From the Departments of Biomedical Engineering, Environmental Medicine, and Medicine, The Johns Hopkins University and Hospital, Baltimore, Maryland 21205.
Dr. Bahler's present address is the Department of Electrical Engineering and Bioengineering Laboratory, Rice University, Houston, Texas 77001
Received:
July 27 1966
Online ISSN: 1540-7748
Print ISSN: 0022-1295
Copyright © 1967 by The Rockefeller University Press
1967
J Gen Physiol (1967) 50 (9): 2239–2253.
Article history
Received:
July 27 1966
Citation
Alan S. Bahler, John T. Fales, Kenneth L. Zierler; The Active State of Mammalian Skeletal Muscle . J Gen Physiol 1 October 1967; 50 (9): 2239–2253. doi: https://doi.org/10.1085/jgp.50.9.2239
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