The effect of acetylcholine on the incorporation of P32 into the individual phosphatides in slices of various structures of the nervous system has been studied. There was a marked stimulation of P32 incorporation into phosphoinositide and phosphatidic acid, but not into phosphatidyl choline and phosphatidyl ethanolamine, in the cat stellate and celiac ganglia in vitro. Acetylcholine stimulated P32 incorporation into certain phosphatides, primarily phosphoinositide and phosphatidic acid, in several structures of the cat and guinea pig brain; there was little or no effect of acetylcholine on phosphatide turnover in the inferior corpora quadrigsemina and cerebellar cortex. The suggestion is made that the phospholipid effect can best be explained as being concerned with the active transport of sodium ions out of the cell across the postsynaptic membrane of cholinergic neurons in response to acetylcholine.
Article|
November 01 1960
The Effects of Acetylcholine on the Turnover of Phosphatidic Acid and Phosphoinositide in Sympathetic Ganglia, and in Various Parts of the Central Nervous System in Vitro
Mabel R. Hokin,
Mabel R. Hokin
From the Department of Physiological Chemistry, University of Wisconsin, Madison
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Lowell E. Hokin,
Lowell E. Hokin
From the Department of Physiological Chemistry, University of Wisconsin, Madison
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Weldon D. Shelp
Weldon D. Shelp
From the Department of Physiological Chemistry, University of Wisconsin, Madison
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Mabel R. Hokin
From the Department of Physiological Chemistry, University of Wisconsin, Madison
Lowell E. Hokin
From the Department of Physiological Chemistry, University of Wisconsin, Madison
Weldon D. Shelp
From the Department of Physiological Chemistry, University of Wisconsin, Madison
Received:
February 23 1960
Online ISSN: 1540-7748
Print ISSN: 0022-1295
Copyright, 1961, by The Rockefeller Institute
1960
J Gen Physiol (1960) 44 (2): 217–226.
Article history
Received:
February 23 1960
Citation
Mabel R. Hokin, Lowell E. Hokin, Weldon D. Shelp; The Effects of Acetylcholine on the Turnover of Phosphatidic Acid and Phosphoinositide in Sympathetic Ganglia, and in Various Parts of the Central Nervous System in Vitro . J Gen Physiol 1 November 1960; 44 (2): 217–226. doi: https://doi.org/10.1085/jgp.44.2.217
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