The number of terramycin-resistant mutants in Bacillus megatherium cultures, their mutation rate, and the growth rate of the wild and mutant cells have been determined under various conditions. These values are in agreement with the following equations (Northrop and Kunitz, 1957):—

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λ = mutation rate, A = growth rate constant of wild cells,

B = growth rate constant of mutants,

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equilibrium. The value of the mutation rate as determined from equation (6) agrees with that found by the null fraction method.

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Copyright, 1957, by The Rockefeller Institute for Medical Research
1957
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