In normal cells of Nitella replacement of NaCl by KCl makes the P.D. much less positive: this is called the potassium effect.

Cells which have lost the potassium effect usually show little or no change of P.D. when NaCl is replaced by KCl but an occasional cell responds after a delay.

It seems possible that the delay may be largely due to the time required for potassium to combine with an organic substance, thus forming a compound which sensitizes the protoplasmic surface to the action of potassium.

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