Cytosolic Ca2+ plays a central role in the regulation of numerous aspects of cellular activity in virtually all cell types. Much of this versatility arises through the diverse mechanisms by which Ca2+ signals are generated and transmitted to act over very different time and distance scales. For example, Ca2+ can act in a very fast and highly localized manner, as in the triggering of neurotransmitter release within microseconds of Ca2+ entry through voltage-gated channels closely apposed to active release zones (Neher 1998); or it can evoke slower responses involving global Ca2+ elevations throughout the cell, as in the generation of Ca2+-dependent Cl− currents by Ca2+ waves that take many seconds to sweep across Xenopus oocytes (Parker and Yao 1994). A common starting point in considering these...
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1 November 2000
Commentary|
October 30 2000
Functional Interactions in Ca2+ Signaling over Different Time and Distance Scales
Jonathan S. Marchant,
Jonathan S. Marchant
aDepartment of Neurobiology and Behavior, Laboratory of Cellular and Molecular Neurobiology, University of California, Irvine, Irvine, California 92697
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Ian Parker
Ian Parker
aDepartment of Neurobiology and Behavior, Laboratory of Cellular and Molecular Neurobiology, University of California, Irvine, Irvine, California 92697
Search for other works by this author on:
Jonathan S. Marchant
aDepartment of Neurobiology and Behavior, Laboratory of Cellular and Molecular Neurobiology, University of California, Irvine, Irvine, California 92697
Ian Parker
aDepartment of Neurobiology and Behavior, Laboratory of Cellular and Molecular Neurobiology, University of California, Irvine, Irvine, California 92697
Received:
October 10 2000
Accepted:
October 11 2000
Online ISSN: 1540-7748
Print ISSN: 0022-1295
© 2000 The Rockefeller University Press
2000
The Rockefeller University Press
J Gen Physiol (2000) 116 (5): 691–696.
Article history
Received:
October 10 2000
Accepted:
October 11 2000
Citation
Jonathan S. Marchant, Ian Parker; Functional Interactions in Ca2+ Signaling over Different Time and Distance Scales. J Gen Physiol 1 November 2000; 116 (5): 691–696. doi: https://doi.org/10.1085/jgp.116.5.691
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