The purpose of the Perspectives in General Physiology is to provide a forum where scientific uncertainties or controversies can be discussed in an authoritative, yet open manner.

The Perspectives are solicited by the editors—often based on recommendations by the advisory editors or members of the editorial board, who may be asked to coordinate the process. To frame the issue, two or more experts will be invited to present a brief point of view on the problem, which will be published back-to-back in The Journal. These Perspectives will be accompanied by one or two editorial paragraphs that introduce the problem—and invite the submission of comments, in the form of letters to the editor, which will be published in a single, predetermined issue (usually four months after publication of the Perspectives). The letters may be no longer than two printed pages (approximately six double-spaced pages) and will be subject to...

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