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Paul Saftig
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Journal Articles

Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis

Julia Bolik, Freia Krause, Marija Stevanovic, Monja Gandraß, Ilka Thomsen, Sarah-Sophie Schacht, Eva Rieser, Miryam Müller, Neele Schumacher, Jürgen Fritsch, Rielana Wichert, Eithan Galun, Juri Bergmann, Christian Röder, Clemens Schafmayer, Jan-Hendrik Egberts, Christoph Becker-Pauly, Paul Saftig, Ralph Lucius, Wulf Schneider-Brachert, Roja Barikbin, Dieter Adam, Matthias Voss, Wolfgang Hitzl, Achim Krüger, Boris Strilic, Irit Sagi, Henning Walczak, Stefan Rose-John, Dirk Schmidt-Arras
Journal: Journal of Experimental Medicine
J Exp Med (2021) 219 (1): e20201039.
https://doi.org/10.1084/jem.20201039
Published: 17 December 2021
View article titled, Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis
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Includes: Supplementary data
Journal Articles

The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain

Janna Schneppenheim, Ralf Dressel, Susann Hüttl, Renate Lüllmann-Rauch, Michael Engelke, Kai Dittmann, Jürgen Wienands, Eeva-Liisa Eskelinen, Irm Hermans-Borgmeyer, Regina Fluhrer, Paul Saftig, Bernd Schröder
Journal: Journal of Experimental Medicine
J Exp Med (2012) 210 (1): 41–58.
https://doi.org/10.1084/jem.20121069
Published: 24 December 2012
View article titled, The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain
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Journal Articles

Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice

Athena Chalaris, Nina Adam, Christian Sina, Philip Rosenstiel, Judith Lehmann-Koch, Peter Schirmacher, Dieter Hartmann, Joanna Cichy, Olga Gavrilova, Stefan Schreiber, Thomas Jostock, Vance Matthews, Robert Häsler, Christoph Becker, Markus F. Neurath, Karina Reiß, Paul Saftig, Jürgen Scheller, Stefan Rose-John
Journal: Journal of Experimental Medicine
J Exp Med (2010) 207 (8): 1617–1624.
https://doi.org/10.1084/jem.20092366
Published: 05 July 2010
View article titled, Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice
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Includes: Supplementary data
Journal Articles

Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac myocyte hypertrophy

Blanche Schroen, Joost J. Leenders, Arie van Erk, Anne T. Bertrand, Mirjam van Loon, Rick E. van Leeuwen, Nard Kubben, Rudy F. Duisters, Mark W. Schellings, Ben J. Janssen, Jacques J. Debets, Michael Schwake, Morten A. Høydal, Stephane Heymans, Paul Saftig, Yigal M. Pinto
Journal: Journal of Experimental Medicine
J Exp Med (2007) 204 (5): 1227–1235.
https://doi.org/10.1084/jem.20070145
Published: 07 May 2007
View article titled, Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac myocyte hypertrophy
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Includes: Supplementary data
Journal Articles

Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway

Cary Esselens, Viola Oorschot, Veerle Baert, Tim Raemaekers, Kurt Spittaels, Lutgarde Serneels, Hui Zheng, Paul Saftig, Bart De Strooper, Judith Klumperman, Wim Annaert
Journal: Journal of Cell Biology
J Cell Biol (2004) 166 (7): 1041–1054.
https://doi.org/10.1083/jcb.200406060
Published: 27 September 2004
View article titled, Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway
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Includes: Supplementary data
Journal Articles

Cell–matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca2+ influx and PKC activation

Osamu Nagano, Daizo Murakami, Dieter Hartmann, Bart de Strooper, Paul Saftig, Takeshi Iwatsubo, Motowo Nakajima, Masanori Shinohara, Hideyuki Saya
Journal: Journal of Cell Biology
J Cell Biol (2004) 165 (6): 893–902.
https://doi.org/10.1083/jcb.200310024
Published: 14 June 2004
View article titled, Cell–matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca2+ influx and PKC activation
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Includes: Supplementary data
Journal Articles

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

Umut Sahin, Gisela Weskamp, Kristine Kelly, Hong-Ming Zhou, Shigeki Higashiyama, Jacques Peschon, Dieter Hartmann, Paul Saftig, Carl P. Blobel
Journal: Journal of Cell Biology
J Cell Biol (2004) 164 (5): 769–779.
https://doi.org/10.1083/jcb.200307137
Published: 01 March 2004
View article titled, Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands
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Journal Articles

The discrepancy between presenilin subcellular localization and γ -secretase processing of amyloid precursor protein

Philippe Cupers, Mustapha Bentahir, Katleen Craessaerts, Isabelle Orlans, Hugo Vanderstichele, Paul Saftig, Bart De Strooper, Wim Annaert
Journal: Journal of Cell Biology
J Cell Biol (2001) 154 (4): 731–740.
https://doi.org/10.1083/jcb.200104045
Published: 13 August 2001
View article titled, The discrepancy between presenilin subcellular localization and γ -secretase processing of amyloid precursor protein
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