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Angus C. Nairn
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Journal Articles

GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer’s disease

Peng Xu, Jerry C. Chang, Xiaopu Zhou, Wei Wang, Michael Bamkole, Eitan Wong, Karima Bettayeb, Lu-Lin Jiang, Timothy Huang, Wenjie Luo, Huaxi Xu, Angus C. Nairn, Marc Flajolet, Nancy Y. Ip, Yue-Ming Li, Paul Greengard
Journal: Journal of Experimental Medicine
J Exp Med (2021) 218 (8): e20202446.
https://doi.org/10.1084/jem.20202446
Published: 22 June 2021
View article titled, GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer’s disease
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Journal Articles

In Memoriam: David C. Gadsby, PhD

Olaf S. Andersen, Angus C. Nairn, Lawrence G. Palmer, Robert M. Shapley
Journal: Journal of General Physiology
J Gen Physiol (2019) 151 (8): 967–969.
https://doi.org/10.1085/jgp.201912400
Published: 16 July 2019
View article titled, In Memoriam: David C. Gadsby, PhD
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Journal Articles

Synaptic NMDA receptor stimulation activates PP1 by inhibiting its phosphorylation by Cdk5

Hailong Hou, Lu Sun, Benjamin A. Siddoway, Ronald S. Petralia, Hongtian Yang, Hua Gu, Angus C. Nairn, Houhui Xia
Journal: Journal of Cell Biology
J Cell Biol (2013) 203 (3): 521–535.
https://doi.org/10.1083/jcb.201303035
Published: 04 November 2013
View article titled, Synaptic NMDA receptor stimulation activates PP1 by inhibiting its phosphorylation by Cdk5
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Includes: Supplementary data
Journal Articles

CaM kinase Iα–induced phosphorylation of Drp1 regulates mitochondrial morphology

Xiao-Jian Han, Yun-Fei Lu, Shun-Ai Li, Taku Kaitsuka, Yasufumi Sato, Kazuhito Tomizawa, Angus C. Nairn, Kohji Takei, Hideki Matsui, Masayuki Matsushita
Journal: Journal of Cell Biology
J Cell Biol (2008) 182 (3): 573–585.
https://doi.org/10.1083/jcb.200802164
Published: 11 August 2008
View article titled, CaM kinase Iα–induced phosphorylation of Drp1 regulates mitochondrial morphology
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Includes: Supplementary data
Journal Articles

Thermodynamics of CFTR Channel Gating: A Spreading Conformational Change Initiates an Irreversible Gating Cycle

László Csanády, Angus C. Nairn, David C. Gadsby
Journal: Journal of General Physiology
J Gen Physiol (2006) 128 (5): 523–533.
https://doi.org/10.1085/jgp.200609558
Published: 16 October 2006
View article titled, Thermodynamics of CFTR Channel Gating: A Spreading Conformational Change Initiates an Irreversible Gating Cycle
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Includes: Supplementary data
Journal Articles

Charge Screening by Internal pH and Polyvalent Cations as a Mechanism for Activation, Inhibition, and Rundown of TRPM7/MIC Channels

J. Ashot Kozak, Masayuki Matsushita, Angus C. Nairn, Michael D. Cahalan
Journal: Journal of General Physiology
J Gen Physiol (2005) 126 (5): 499–514.
https://doi.org/10.1085/jgp.200509324
Published: 31 October 2005
View article titled, Charge Screening by Internal pH and Polyvalent Cations as a Mechanism for Activation, Inhibition, and Rundown of TRPM7/MIC Channels
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Journal Articles

Regulation of the interaction between PIPKIγ and talin by proline-directed protein kinases

Sang Yoon Lee, Sergey Voronov, Kresimir Letinic, Angus C. Nairn, Gilbert Di Paolo, Pietro De Camilli
Journal: Journal of Cell Biology
J Cell Biol (2005) 168 (5): 789–799.
https://doi.org/10.1083/jcb.200409028
Published: 28 February 2005
View article titled, Regulation of the interaction between PIPKIγ and talin by proline-directed protein kinases
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Journal Articles

Preferential Phosphorylation of R-domain Serine 768 Dampens Activation of CFTR Channels by PKA

László Csanády, Donna Seto-Young, Kim W. Chan, Cristina Cenciarelli, Benjamin B. Angel, Jun Qin, Derek T. McLachlin, Andrew N. Krutchinsky, Brian T. Chait, Angus C. Nairn, David C. Gadsby
Journal: Journal of General Physiology
J Gen Physiol (2005) 125 (2): 171–186.
https://doi.org/10.1085/jgp.200409076
Published: 18 January 2005
View article titled, Preferential Phosphorylation of R-domain Serine 768 Dampens Activation of CFTR Channels by PKA
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Includes: Supplementary data
Journal Articles

Functional Roles of Nonconserved Structural Segments in CFTR's NH2-terminal Nucleotide Binding Domain

László Csanády, Kim W. Chan, Angus C. Nairn, David C. Gadsby
Journal: Journal of General Physiology
J Gen Physiol (2004) 125 (1): 43–55.
https://doi.org/10.1085/jgp.200409174
Published: 13 December 2004
View article titled, Functional Roles of Nonconserved Structural Segments in CFTR's NH2-terminal Nucleotide Binding Domain
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Journal Articles

Prolonged Nonhydrolytic Interaction of Nucleotide with CFTR's NH2-terminal Nucleotide Binding Domain and its Role in Channel Gating

Claudia Basso, Paola Vergani, Angus C. Nairn, David C. Gadsby
Journal: Journal of General Physiology
J Gen Physiol (2003) 122 (3): 333–348.
https://doi.org/10.1085/jgp.200308798
Published: 25 August 2003
View article titled, Prolonged Nonhydrolytic Interaction of Nucleotide with CFTR's NH2-terminal Nucleotide Binding Domain and its Role in Channel Gating
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Journal Articles

On the Mechanism of MgATP-dependent Gating of CFTR Cl− Channels

Paola Vergani, Angus C. Nairn, David C. Gadsby
Journal: Journal of General Physiology
J Gen Physiol (2002) 121 (1): 17–36.
https://doi.org/10.1085/jgp.20028673
Published: 16 December 2002
View article titled, On the Mechanism of MgATP-dependent Gating of CFTR Cl− Channels
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Journal Articles

Distinct Mg2+-dependent Steps Rate Limit Opening and Closing of a Single CFTR Cl− Channel

Athanasios G. Dousmanis, Angus C. Nairn, David C. Gadsby
Journal: Journal of General Physiology
J Gen Physiol (2002) 119 (6): 545–559.
https://doi.org/10.1085/jgp.20028594
Published: 28 May 2002
View article titled, Distinct Mg2+-dependent Steps Rate Limit Opening and Closing of a Single CFTR Cl− Channel
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Journal Articles

Severed Channels Probe Regulation of Gating of Cystic Fibrosis Transmembrane Conductance Regulator by Its Cytoplasmic Domains

László Csanády, Kim W. Chan, Donna Seto-Young, David C. Kopsco, Angus C. Nairn, David C. Gadsby
Journal: Journal of General Physiology
J Gen Physiol (2000) 116 (3): 477–500.
https://doi.org/10.1085/jgp.116.3.477
Published: 28 August 2000
View article titled, Severed Channels Probe Regulation of Gating of Cystic Fibrosis Transmembrane Conductance Regulator by Its Cytoplasmic Domains
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Includes: Supplementary data
Journal Articles

Severed Molecules Functionally Define the Boundaries of the Cystic Fibrosis Transmembrane Conductance Regulator's Nh2-Terminal Nucleotide Binding Domain

Kim W. Chan, László Csanády, Donna Seto-Young, Angus C. Nairn, David C. Gadsby
Journal: Journal of General Physiology
J Gen Physiol (2000) 116 (2): 163–180.
https://doi.org/10.1085/jgp.116.2.163
Published: 17 July 2000
View article titled, Severed Molecules Functionally Define the Boundaries of the Cystic Fibrosis Transmembrane Conductance Regulator's Nh2-Terminal Nucleotide Binding Domain
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Journal Articles

Actions of Genistein on Cystic Fibrosis Transmembrane Conductance Regulator Channel Gating : Evidence for Two Binding Sites with Opposite Effects

Fei Wang, Shawn Zeltwanger, Iris C.-H. Yang, Angus C. Nairn, Tzyh-Chang Hwang
Journal: Journal of General Physiology
J Gen Physiol (1998) 111 (3): 477–490.
https://doi.org/10.1085/jgp.111.3.477
Published: 01 March 1998
View article titled, Actions of Genistein on Cystic Fibrosis Transmembrane Conductance Regulator Channel Gating : Evidence for Two Binding Sites with Opposite Effects
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