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JCB65: Cytoskeleton

In the second collection celebrating our 65th anniversary, we highlight early studies of the network of tubules and proteins conferring shape and motility to the cell and its subcompartments. Many key reagents and tools first published in JCB, such as the introduction of latrunculin to study actin dynamics, enabled researchers to explore the functions, ultrastructure, and composition of the cytoskeleton. Find seminal discoveries, such as that of tubulin, the elucidation of the functions of microtubules in the yeast cell cycle, early studies of actin nucleators, the first ultrastructural description of the contractile ring during cell cleavage, and the description of intermediate filaments. We also include early studies of the functions of cytoskeletal motors and the basic principles governing the organization and dynamics of the cytoskeleton in cells. If we missed your favorite JCB study, tweet to @JCellBiol using the hashtag #JCB65, or email us at Find more 65th anniversary collections or browse our From the Archive series.

Image from Svitkina and Borisy, 1999.

Special Collection Image
Kimihide Hayakawa; Hitoshi Tatsumi; Masahiro Sokabe
Kristen J. Verhey; Debra Meyer; Reneé Deehan; John Blenis; Bruce J. Schnapp; Tom A. Rapoport; Ben Margolis
Tatyana M. Svitkina; Gary G. Borisy
A. Ebneth; R. Godemann; K. Stamer; S. Illenberger; B. Trinczek; E.-M. Mandelkow; E. Mandelkow
James E. Bear; John F. Rawls; Charles L. Saxe, III
Sally H. Zigmond; Michael Joyce; Changsong Yang; Kevin Brown; Minzhou Huang; Martin Pring
Michelle Moritz; Yixian Zheng; Bruce M. Alberts; Karen Oegema
Douglas G. Cole; Dennis R. Diener; Amy L. Himelblau; Peter L. Beech; Jason C. Fuster; Joel L. Rosenbaum
Amy McGough; Brian Pope; Wah Chiu; Alan Weeds
Janet L. Carminati; Tim Stearns
Kathryn R. Ayscough; Joel Stryker; Navin Pokala; Miranda Sanders; Phil Crews; David G. Drubin
Richard L. Klemke; Shuang Cai; Ana L. Giannini; Patricia J. Gallagher; Primal de Lanerolle; David A. Cheresh
S Miyamoto; H Teramoto; O A Coso; J S Gutkind; P D Burbelo; S K Akiyama; K M Yamada
A A Hyman; D Chrétien; I Arnal; R H Wade
L M Machesky; S J Atkinson; C Ampe; J Vandekerckhove; T D Pollard
F Aniento; N Emans; G Griffiths; J Gruenberg
JM Ervasti; KP Campbell
F Gittes; B Mickey; J Nettleton; J Howard
L G Tilney; D J DeRosier; M S Tilney
L G Tilney; D J DeRosier; A Weber; M S Tilney
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