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André Nussenzweig
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Journal Articles

CtIP-mediated resection is essential for viability and can operate independently of BRCA1

Federica Polato, Elsa Callen, Nancy Wong, Robert Faryabi, Samuel Bunting, Hua-Tang Chen, Marina Kozak, Michael J. Kruhlak, Colleen R. Reczek, Wen-Hwa Lee, Thomas Ludwig, Richard Baer, Lionel Feigenbaum, Stephen Jackson, André Nussenzweig
Journal: Journal of Experimental Medicine
J Exp Med (2014) 211 (6): 1027–1036.
https://doi.org/10.1084/jem.20131939
Published: 19 May 2014
View article titled, CtIP-mediated resection is essential for viability and can operate independently of BRCA1
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Journal Articles

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4

Cristian Boboila, Catherine Yan, Duane R. Wesemann, Mila Jankovic, Jing H. Wang, John Manis, Andre Nussenzweig, Michel Nussenzweig, Frederick W. Alt
Journal: Journal of Experimental Medicine
J Exp Med (2013) 210 (3): 641.
https://doi.org/10.1084/jem.200924492103c
Published: 11 March 2013
View article titled, Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4
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Journal Articles

Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching

Anne Bothmer, Philipp C. Rommel, Anna Gazumyan, Federica Polato, Colleen R. Reczek, Matthias F. Muellenbeck, Sonja Schaetzlein, Winfried Edelmann, Phang-Lang Chen, Robert M. Brosh, Jr., Rafael Casellas, Thomas Ludwig, Richard Baer, André Nussenzweig, Michel C. Nussenzweig, Davide F. Robbiani
Journal: Journal of Experimental Medicine
J Exp Med (2012) 210 (1): 115–123.
https://doi.org/10.1084/jem.20121975
Published: 17 December 2012
View article titled, Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching
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Journal Articles

Loss of ATM kinase activity leads to embryonic lethality in mice

Jeremy A. Daniel, Manuela Pellegrini, Baeck-Seung Lee, Zhi Guo, Darius Filsuf, Natalya V. Belkina, Zhongsheng You, Tanya T. Paull, Barry P. Sleckman, Lionel Feigenbaum, André Nussenzweig
Journal: Journal of Cell Biology
J Cell Biol (2012) 198 (3): 295–304.
https://doi.org/10.1083/jcb.201204035
Published: 06 August 2012
View article titled, Loss of ATM kinase activity leads to embryonic lethality in mice
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Includes: Supplementary data
Journal Articles

Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair

Shichuan Zhang, Hirohiko Yajima, HoangDinh Huynh, Junke Zheng, Elsa Callen, Hua-Tang Chen, Nancy Wong, Samuel Bunting, Yu-Fen Lin, Mengxia Li, Kyung-Jone Lee, Michael Story, Eric Gapud, Barry P. Sleckman, André Nussenzweig, Cheng Cheng Zhang, David J. Chen, Benjamin P.C. Chen
Journal: Journal of Cell Biology
J Cell Biol (2011) 193 (2): 295–305.
https://doi.org/10.1083/jcb.201009074
Published: 11 April 2011
View article titled, Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair
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Includes: Supplementary data
Journal Articles

Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8

Margarida Almeida Santos, Michael S.Y. Huen, Mila Jankovic, Hua-Tang Chen, Andrés J. López-Contreras, Isaac A. Klein, Nancy Wong, Juan L.R. Barbancho, Oscar Fernandez-Capetillo, Michel C. Nussenzweig, Junjie Chen, André Nussenzweig
Journal: Journal of Experimental Medicine
J Exp Med (2010) 207 (5): 973–981.
https://doi.org/10.1084/jem.20092308
Published: 12 April 2010
View article titled, Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8
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Includes: Supplementary data
Journal Articles

53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination

Anne Bothmer, Davide F. Robbiani, Niklas Feldhahn, Anna Gazumyan, Andre Nussenzweig, Michel C. Nussenzweig
Journal: Journal of Experimental Medicine
J Exp Med (2010) 207 (4): 855–865.
https://doi.org/10.1084/jem.20100244
Published: 05 April 2010
View article titled, 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination
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Includes: Supplementary data
Journal Articles

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4

Cristian Boboila, Catherine Yan, Duane R. Wesemann, Mila Jankovic, Jing H. Wang, John Manis, Andre Nussenzweig, Michel Nussenzweig, Frederick W. Alt
Journal: Journal of Experimental Medicine
J Exp Med (2010) 207 (2): 417–427.
https://doi.org/10.1084/jem.20092449
Published: 08 February 2010
View article titled, Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4
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Includes: Supplementary data
Journal Articles

Chromosomal reinsertion of broken RSS ends during T cell development

John D. Curry, Danae Schulz, Cynthia J. Guidos, Jayne S. Danska, Lauryl Nutter, Andre Nussenzweig, Mark S. Schlissel
Journal: Journal of Experimental Medicine
J Exp Med (2007) 204 (10): 2293–2303.
https://doi.org/10.1084/jem.20070583
Published: 04 September 2007
View article titled, Chromosomal reinsertion of broken RSS ends during T cell development
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Includes: Supplementary data
Journal Articles

RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females

Sergey Kuznetsov, Manuela Pellegrini, Kristy Shuda, Oscar Fernandez-Capetillo, Yilun Liu, Betty K. Martin, Sandra Burkett, Eileen Southon, Debananda Pati, Lino Tessarollo, Stephen C. West, Peter J. Donovan, Andre Nussenzweig, Shyam K. Sharan
Journal: Journal of Cell Biology
J Cell Biol (2007) 176 (5): 581–592.
https://doi.org/10.1083/jcb.200608130
Published: 20 February 2007
View article titled, RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females
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Includes: Supplementary data
Journal Articles

53BP1 is required for class switch recombination

In Special Collection:
JCB65: DNA Replication and Repair
Irene M. Ward, Bernardo Reina-San-Martin, Alexandru Olaru, Kay Minn, Koji Tamada, Julie S. Lau, Marilia Cascalho, Lieping Chen, Andre Nussenzweig, Ferenc Livak, Michel C. Nussenzweig, Junjie Chen
Journal: Journal of Cell Biology
J Cell Biol (2004) 165 (4): 459–464.
https://doi.org/10.1083/jcb.200403021
Published: 24 May 2004
View article titled, 53BP1 is required for class switch recombination
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Journal Articles

Potential Role of Phosphatidylinositol 3 Kinase, rather than DNA-dependent Protein Kinase, in CpG DNA–induced Immune Activation

Ken J. Ishii, Fumihiko Takeshita, Ihsan Gursel, Mayda Gursel, Jacqueline Conover, Andre Nussenzweig, Dennis M. Klinman
Journal: Journal of Experimental Medicine
J Exp Med (2002) 196 (2): 269–274.
https://doi.org/10.1084/jem.20020773
Published: 08 July 2002
View article titled, Potential Role of Phosphatidylinositol 3 Kinase, rather than DNA-dependent Protein Kinase, in CpG DNA–induced Immune Activation
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Journal Articles

The Role of Recombination Activating Gene (RAG) Reinduction in Thymocyte Development in Vivo

Nikos Yannoutsos, Patrick Wilson, Wong Yu, Hua Tang Chen, Andre Nussenzweig, Howard Petrie, Michel C. Nussenzweig
Journal: Journal of Experimental Medicine
J Exp Med (2001) 194 (4): 471–480.
https://doi.org/10.1084/jem.194.4.471
Published: 20 August 2001
View article titled, The Role of Recombination Activating Gene (RAG) Reinduction in Thymocyte Development in Vivo
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Journal Articles

Immature Thymocytes Undergoing Receptor Rearrangements Are Resistant to an Atm-Dependent Death Pathway Activated in Mature T Cells by Double-Stranded DNA Breaks

Avinash Bhandoola, Benjamin Dolnick, Nihal Fayad, Andre Nussenzweig, Alfred Singer
Journal: Journal of Experimental Medicine
J Exp Med (2000) 192 (6): 891–898.
https://doi.org/10.1084/jem.192.6.891
Published: 18 September 2000
View article titled, Immature Thymocytes Undergoing Receptor Rearrangements Are Resistant to an Atm-Dependent Death Pathway Activated in Mature T Cells by Double-Stranded DNA Breaks
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Journal Articles

Ku70 Is Required for DNA Repair but Not for T Cell Antigen Receptor Gene Recombination In Vivo

Honghai Ouyang, Andre Nussenzweig, Akihiro Kurimasa, Vera da Costa Soares, Xiaoling Li, Carlos Cordon-Cardo, Wen-hui Li, Nge Cheong, Michel Nussenzweig, George Iliakis, David J. Chen, Gloria C. Li
Journal: Journal of Experimental Medicine
J Exp Med (1997) 186 (6): 921–929.
https://doi.org/10.1084/jem.186.6.921
Published: 15 September 1997
View article titled, Ku70 Is Required for DNA Repair but Not for T Cell Antigen Receptor Gene Recombination In Vivo
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