Neuroimmunology and Neurodegeneration 2026

This collection covers a broad range of topics including autoimmune inflammation, CNS clearance, the characterization of vagal neuroimmune circuits, the role of innate immune cells in poststroke neuroinflammation, Alzheimer’s disease, and the effect of inflammation on enteric nervous system integrity.

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Image © 2026 Kurapati et al.

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Brief Definitive Report
Brain border α-synuclein impairs CNS clearance
Taylor J. Stevenson; Luca Vinnell; Samuel J.C. McCullough; Daniel X. Flyger; Blake Highet; James A. Wiseman; Ben Watkin; Kate Hitpass Romero; Victoria F. Low; Amy M. Smith; Angela Wu; Dahna M. Fong; Natasha L. Grimsey; Birger V. Dieriks; Clinton P. Turner; Deborah Young; Maurice A. Curtis; Richard L.M. Faull; Mike Dragunow; Justin Rustenhoven
https://doi.org/10.1084/jem.20251245
Review
Vagal neuroimmune circuits
Tomás S. Huerta; Kevin J. Tracey; Isaac M. Chiu; Eric H. Chang
https://doi.org/10.1084/jem.20260135
Article
Refinement of spinal sensory-motor circuits
Danny Florez-Paz; George Z. Mentis
https://doi.org/10.1084/jem.20251329
Brief Definitive Report
Bridging veins govern discrepant CSF efflux into dura
Lingli Yan; Senthil Kumaran Satyanarayanan; Di Huang; Yanzhu Qin; Di Wu; Jianheng Lai; Dajiang Qin; Huanxing Su
https://doi.org/10.1084/jem.20252556
Article
Secondary microglial formation centers
Chenyun Song; Xinyu Chen; Rong Ji; Yang Liu; Yawen Han; Fangzhou Ye; Ling Zhang; Li Li; Lu Gao; Qizhi He; Lixiang Ma; Hexige Saiyin
https://doi.org/10.1084/jem.20251801
Article
Metabolic adaptation of monocytes in stroke brain
Weijie Chen; Xin Wang; Tingting Huang; Yan Li; Chen Chen; Yueman Zhang; Wanqing Xie; Dan Tang; Qiuyue Fan; Rui Pang; Jiemin Yin; Tim Sparwasser; Zhenghong Wang; Arthur Liesz; Yu Gan; Weifeng Yu; Florent Ginhoux; Peiying Li
https://doi.org/10.1084/jem.20242025
Article
Monocytes remodel the enteric nervous system
Sravya Kurapati; Changsik Shin; Krisztina Szabo; Yu Liu; Azree Z. Ashraf; Balazs Koscso; Chinmayee Dash; Katherine L. Kruckow; Leonardo E. Navarro; Amanda M. Clark; Monalee Saha; Sushma Nagaraj; Wenhui Wang; Jun Zhu; Kevin Brown; Travis Thomson; Natalia Shulzhenko; Andrey Morgun; Christina E. Baer; Shanthi Srinivasan; Subhash Kulkarni; Pankaj J. Pasricha; Lauren A. Peters; Milena Bogunovic
https://doi.org/10.1084/jem.20251761
Article
NIK and IL-23 in myeloid cells in EAE
Nishada S. Ramphal; Xinyuan Liu; Ilaria Palagi; Rebecca Jasser; Alma N. Mohebiany; Matthias Klein; Frederike Westermann; Sinduya Krishnarajah; Tommy Regen; Tobias Bopp; Burkhard Becher; Ari Waisman
https://doi.org/10.1084/jem.20242294
Article
CRH+ BNST neurons encode IL-1β signals
Okito Hashimoto; Tyler D. Hepler; Aisling Tynan; Alejandro Torres; Jian Hua Li; Michael Brines; Kevin J. Tracey; Sangeeta S. Chavan
https://doi.org/10.1084/jem.20252000
Review
The cribriform plate: CNS–immune hub
Collin J. Laaker; Sophia M. Vrba; Jenna M. Port; Martin Hsu; Cameron M. Baenen; Melinda Herbath; Thanthrige Thiunuwan Priyathilaka; Matyas Sandor; Zsuzsanna Fabry
https://doi.org/10.1084/jem.20251871
Brief Definitive Report
Amyloidosis of ACE points in AD
Leon C.D. Smyth; Daan Verhaege; Elio Standen-Bloom; Yue Wu; Yiming Gan; Steffen E. Storck; Pavle Boskovic; Benjamin A. Plog; Tornike Mamuladze; Jose A. Mazzitelli; Zhuoying Wang; Daniel D. Lee; Gwendalyn J. Randolph; Antoine Drieu; Katherine E. Schwetye; Song Hu; Daniel S. Reich; Douglas H. Kelley; Rupal I. Mehta; Jonathan Kipnis
https://doi.org/10.1084/jem.20251860
Review
ApoE-calypse tau: ApoE–tau synergy in AD
Matthew Paul Lennol; Chiara Bordier; Léana Kamelher; Jason D. Ulrich; David M. Holtzman; Maud Gratuze
https://doi.org/10.1084/jem.20250965
Article
ILC2s promote angiogenic sprouting after stroke
An Ping; Fan Yang; Lingxiao Lu; Xiaotao Zhang; Jianan Lu; Huaming Li; Yichen Gu; Ziyang Jin; Jianmin Zhang; Ligen Shi
https://doi.org/10.1084/jem.20241830