Figure 5.
Panel A shows a line graph depicting the relationship between sarcomere length (in micrometers) and calcium signal (F360/F380) in left ventricular cardiomyocytes (LVCM) and LVCM treated with SMTC. The solid line represents LVCM, while the dotted line represents LVCM/SMTC. The x-axis shows the calcium signal ranging from 1.0 to 1.6, and the y-axis shows the sarcomere length ranging from 1.60 to 1.80 micrometers. Panel B shows a line graph showing the relationship between sarcomere length and calcium signal in right ventricular cardiomyocytes (RVCM) and RVCM treated with SMTC. The solid line represents RVCM, while the dotted line represents RVCM/SMTC. The x-axis shows the calcium signal ranging from 1.0 to 1.6, and the y-axis shows the sarcomere length ranging from 1.60 to 1.80 micrometers.
Ca 2+ -sarcomere length (SL) relationship in LVCM and RVCM with or without SMTC. (A) Cell-level phase-plane plots showing the relationship between sarcomere length and intracellular Ca2+ signal (F360/F380) in LVCM (solid line) and LVCM/SMTC (dotted line). Traces represent averaged trajectories constructed from individual cardiomyocytes across the full Ca2+ transient. (B) Corresponding Ca2+-SL relationships in RVCM (solid line) and RVCM/SMTC (dotted line).