Each box plot shows the distribution of measurements from individual cardiomyocytes pooled across animals. Panel A shows the resting calcium ion level expressed as F360 divided by F380 at rest, with the y-axis ranging from 0.8 to 1.4. Panel B displays the peak calcium ion signal, expressed as F360 divided by F380 at peak, with the y-axis ranging from 0 to 2.5. Panel C illustrates the calcium ion transient amplitude, expressed as F360 divided by F380 at peak, with the y-axis ranging from 0 to 1.5. Panel D presents the time to 10 percent decay of the calcium ion transient in milliseconds, with the y-axis ranging from 0 to 60. Panel E shows the time to 50 percent decay of the calcium ion transient in milliseconds, with the y-axis ranging from 0 to 200. Panel F depicts the time to 90 percent decay of the calcium ion transient in milliseconds, with the y-axis ranging from 0 to 500. Each plot represents the interquartile range, with the median indicated by a horizontal line, and whiskers denote the minimum and maximum values.
Cell-level distributions of Ca 2+ transient parameters in LVCM and RVCM with or without SMTC. (A) Resting Ca2+ level expressed as F360/F380 at rest. (B) Peak Ca2+ signal (F360/F380 at peak). (C) Ca2+ transient amplitude (F360/F380 at peak). (D) Time to 10% decay of the Ca2+ transient. (E) Time to 50% decay of the Ca2+ transient. (F) Time to 90% decay of the Ca2+ transient. Data are presented as box-and-whisker plots showing cell-level measurements from LVCM, LVCM + SMTC, RVCM, and RVCM + SMTC. Boxes represent the interquartile range with the median indicated by a horizontal line; whiskers denote the minimum and maximum values. Each box reflects the distribution of Ca2+ transient parameters obtained from individual cardiomyocytes pooled across animals.