Panel A: A cross-sectional view of skin tissue showing dyskeratotic keratinocytes in the stratum corneum (white arrows), focal vacuolar interface change (blue arrows), and scattered perivascular mixed inflammation in the superficial dermis. Panel B: Another cross-sectional view of skin tissue highlighting similar features with dyskeratotic keratinocytes (white arrows) and vacuolar interface change (blue arrows). Panel C: A cross-sectional image displaying dyskeratotic keratinocytes (white arrows) and inflammation in the superficial dermis. Panel D: A cross-sectional view showing dyskeratotic keratinocytes (white arrows) and perivascular inflammation. Panel E: A medium power view of skin tissue demonstrating prominent vacuolar interface change (blue arrow) and dyskeratotic keratinocytes (white arrows). Panel F: A medium power view showing a predominantly neutrophilic pattern of superficial and perivascular inflammation (yellow arrow) and dyskeratotic keratinocytes (white arrows).
Histological features of skin biopsy in patients with Still's disease. (A–D) Spectrum of histopathological changes in skin biopsy specimens of patients with AOSD (hematoxylin and eosin stain). (A–D) Panels represent four unique patients from one center: Sections show DKs in the stratum corneum of the epidermis (white arrows), focal vacuolar interface change (blue arrows), and scattered perivascular mixed inflammation composed of lymphocytes, eosinophils, and neutrophils in the superficial dermis. The scale bars each represent 25 μm. (E and F) Panels demonstrate medium-power-view (×200) findings noted in two different patients from another center. E demonstrates prominent vacuolar interface (blue arrow), and F shows a predominantly neutrophilic pattern of superficial and perivascular inflammation (yellow arrow). Both cases show superficial DKs, as noted with the white arrows.