Figure 5.
Panel A shows two UMAP plots: one with colors corresponding to cell types and another with colors corresponding to samples. Panel B includes trajectory analysis of the B cell lineage for Patient 1 and controls, along with a pseudotime trajectory denoting the differentiation of the B cell lineage. Panel C displays the B cell lineage for Patient 1 and controls according to annotation, with labels for Hematopoietic Stem Cells (HSC), Lympho-Myeloid Primed Progenitors (LMPP), and Common Lymphoid Progenitors (CLP). Panel D shows the B cell lineage for Patient 1 and controls according to pseudotime analysis. Panel E illustrates the expression of HYOU1 in the B cell lineage for Patient 1 and controls.
scRNA-seq analyses of bone marrow cells. (A) UMAP plot showing single-cell transcriptome of bone marrow cells in patient 1 and controls (left, colors correspond to cell type; right, colors correspond to samples). (B) Trajectory analysis of the B cell lineage of patient 1 and controls (left); pseudotime trajectory denoting the differentiation of the B cell lineage (right). (C) The B cell lineage of patient 1 (left) and the controls (right), according to annotation. LMPP, lympho-myeloid primed progenitors; CLP, common lymphoid progenitors. (D) The B cell lineage of patient 1 (left) and the controls (right) according to pseudotime analysis. (E) Expression of HYOU1 in the B cell lineage of patient 1 and controls.