Figure 2.
Panel A shows three UMAP visualizations. Each plot has UMAP1 on the x-axis and UMAP2 on the y-axis. The first two plots represent Control A and Control B, while the third plot represents Patient 1. The color scale indicates expression levels of CD14 and CD19, with blue representing lower levels and red representing higher levels. Panel B shows three scatter plots. Each plot has CD66b on the x-axis and side scatter (SSC) on the y-axis. The first two plots represent Control A and Control B, while the third plot represents Patient 1. The scatter plots depict granulocytes, with Patient 1 showing considerably lower SSC-A indicating lower granularity.
A depiction of flow cytometry experiments in patient 1. (A) The UMAP visualization depicts the analysis of white blood cells obtained from flow cytometry data of patient 1 and 2 controls, colored based on expression levels of CD14 and CD19. The granulocytes of patient 1 are different in the expression of CD14. Almost no CD19+ B cells are observed in patient 1. (B) Flow cytometry scatter plot depicting granulocytes in patient 1 and 2 controls, labelled with CD66b on the x-axis and side scatter (SSC) on the y-axis. The patient’s granulocytes have considerably lower SSC-A, indicating lower granularity.