Figure 3.
Panel A: A table showing the distribution of HLA-DQ genotypes among individuals with and without celiac disease (CeD). The table has four rows and three columns. The columns are labeled DQ, HLA-DQ haplotypes, CeD (n equals 2,899), and Non-CeD (n equals 14,495). The rows list different HLA-DQ genotypes categorized by risk level: high, moderate, low, or no risk. Each row provides the specific HLA-DQ haplotypes and the number and percentage of individuals with and without CeD for each genotype. Panel B: A bar chart showing the frequency of individuals carrying HLA-DQ2.5, either in cis or in trans, among seropositive CeD patients and across genetic ancestry groups (European, Admixed American, and African) for both the CeD and control cohorts. The chart is divided into sections for each ancestry group, with bars representing the percentage of individuals with different HLA-DQ genotypes. The chart includes a legend indicating the different HLA-DQ genotypes and their corresponding colors.
HLA-DQ genotype distribution and ancestry-specific effects in CeD. (A) Distribution of HLA-DQ genotypes based on the four known CeD-compatible HLA-DQ haplotypes among individuals with and without CeD. Genotypes were further categorized by risk level: high, moderate, low, or no risk (none). HLA-DQ 7.5/X was used as the reference, and P values were FDR-adjusted. (B) HLA-DQ genotype distribution among seropositive CeD patients and across genetic ancestry groups (European, admixed American, and African) for both the CeD and control cohorts. The frequency of individuals carrying HLA-DQ2.5, either in cis or in trans, is presented for each group.