Figure 2.
Panel A: A table showing linkage data for the DQA1*05:01-DQB1*02:01-DRB1*03:01 haplotype across European, Admixed American, and African populations. The table includes total counts and percentages of linkage with specific alleles. Panel B: A table listing HLA alleles overrepresented in individuals with CeD compared to controls, including their frequencies and odds ratios. Panel C: Bar graphs displaying allele frequencies for HLA-DQ2.5 and other alleles in linkage disequilibrium with HLA-DQ2.5 across different genetic ancestries and CeD statuses. The graphs show allele frequencies for European and Admixed American populations, with separate bars for non-CeD and CeD groups.
HLA alleles and linkage disequilibrium patterns with DQ2.5 in CeD patients and matched controls across ancestries. (A) Cross-ancestry LD between HLA-DQA1, HLA-DQB1, and HLA-DRB1 in DQ2.5 carriers. (B) Table showing HLA alleles from the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, and -DRB1 loci overrepresented in individuals with CeD, with a frequency at least 1% higher in such individuals than in matched controls. (C) Allele frequencies for HLA-DQ2.5 and other alleles in linkage disequilibrium with HLA-DQ2.5 (A1, B8, C7, DRB3, and DPB1) across different genetic ancestries and CeD statuses.