Six sets of line graphs, each set consisting of two graphs side by side. Each set represents data for different patients, labeled A through F. The left graph in each set is a line graph showing platelet (PLT) and albumin (ALB) levels over days post admission. The right graph in each set is a combination of line graphs showing levels of creatine kinase-MB mass (CK-MB mass), high-sensitivity cardiac troponin I (hs-cTNI), B-type natriuretic peptide (BNP), and C-reactive protein (CRP) over days post admission. The x-axis for all graphs represents days post admission, ranging from 0 to 12. The y-axis for the left graphs represents PLT levels from 125 to 350 × 10 superscript 9 per liter and ALB levels from 40 to 55 grams per liter. The y-axis for the right graphs represents CK-MB mass from 0.6 to 6.3 micrograms per liter, hs-cTNI from 0 to 17.5 picograms per milliliter, BNP from 0 to 100 nanograms per liter, and CRP from 0 to 10 milligrams per liter. Each graph includes horizontal dashed lines indicating the lowest or highest healthy reference values for the respective parameters. Panel A shows data for a patient with neutralizing antibodies (NAbs) against interferon-omega (IFN-omega) only, Panel B for a patient with NAbs against interferon-alpha 2 (IFN-alpha 2) and IFN-omega, Panel C for a patient with NAbs against IFN-alpha 2 only, and Panels D, E, and F show data for dengue hemorrhagic fever (DHF) NAb-negative patients. The graphs illustrate trends in platelet recovery, albumin levels, and markers of cardiac injury and inflammation over the hospitalization period.
Clinical laboratory parameters in dengue patients with IFN-I NAbs. (A–F) The longitudinal clinical data for NAb(+) patients (A–C) and DHF NAb(−) patients (D–F). The data on day 0 represent the outpatient data or the data from other hospitals prior to hospitalization. We separately show the clinical parameters related to hemorrhage (left) and cardiac injury (right). The healthy reference ranges for all parameters are indicated in parentheses above the figure. The horizontal dashed lines in the left figure represent the lowest healthy reference values for the parameters PLT (green) and ALB (dark blue), respectively. In the right panel, the horizontal dashed lines correspond to the highest healthy reference values for CK-MB mass (blue), hs-cTnI (dark red), BNP (gray), and CRP (orange). PLT, platelet.