Panel A shows alanine aminotransferase (ALT) levels in units per liter, Panel B shows aspartate aminotransferase (AST) levels in units per liter, Panel C shows total bilirubin (TBil) levels in micromoles per liter, and Panel D shows creatinine levels in micromoles per liter. Panel E shows D-dimer levels in milligrams per liter, Panel F shows fibrinogen levels in grams per liter, Panel G shows prothrombin time (PT) in seconds, and Panel H shows activated partial thromboplastin time (APTT) in seconds. Each plot compares four groups: NAb positive, DSS NAb negative, DHF NAb negative, and DF NAb negative, with a larger red dot indicating the DSS NAb positive patient. The gray-shaded areas represent healthy reference ranges. Statistical analysis using the Mann-Whitney U test is indicated with p-values above the plots.
Correlations between clinical laboratory parameters and NAbs against IFNs-I in dengue patients. (A–H) Clinical laboratory parameters of NAb(+), DSS NAb(−), DHF NAb(−), and DF NAb(−) patients at the most severe stage, including parameters of hepatic injury (A, alanine aminotransferase, ALT; B, aspartate aminotransferase, AST), renal injury (C, total bilirubin, TBil; D, creatinine, Cr), and coagulation (E, D-dimer; F, fibrinogen, FIB; G, prothrombin time, PT; H, activated partial thromboplastin time, APTT). The parameters of the DSS NAb(+) patient were shown as a larger red dot compared with others. Data are median with interquartile range. Statistical analysis was performed using the Mann‒Whitney U test. The gray-shaded area represents the healthy reference range for these parameters.