Panel A shows a forest plot of odds ratios (OR) with 95 percent confidence intervals (CI) for various factors including sex, age, hypertension, diabetes, heart disease, renal disease, malignant tumor, and neuropsychopathy. The x-axis represents the odds ratio (OR) on a logarithmic scale, and the y-axis lists the factors. Panel B presents another forest plot focusing on the effects of age on the prevalence of IFN-I NAbs, with similar axes and factors. Panels C to G display horizontal bar graphs showing the age distribution of patients in different groups: all patients, NAb(plus), DSS NAb(minus), DHF NAb(minus), and DF NAb(minus). The x-axis represents the percentage of patients, and the y-axis lists age groups (16-50, 50-69, and 70 years or more). Notable trends include higher prevalence of NAbs in patients older than 65 years and variations in age distribution across different patient groups.
Association of age with the prevalence of IFN-I NAbs in dengue patients. (A) Effects of sex, age, and comorbidities on the prevalence of NAbs in dengue patients. Firth’s bias-corrected logistic regression was used to assess the association between clinical characteristics (sex, age, and comorbidities) and NAbs (defined as the combined anti–IFN-α2 NAbs and anti–IFN-ω NAbs group) with adjusted ORs and 95% CIs. A P value <0.05 was considered statistically significant. “yo” is an abbreviation for “years old.” (B) Effects of age on the prevalence of IFN-I NAbs in dengue patients. Firth’s bias-corrected logistic regression was used to assess the association between age and IFN-I NAbs (analysis of age with anti–IFN-α2 NAbs, anti–IFN-ω NAbs, anti–IFN-α2 and/or anti–IFN-ω NAbs, anti–IFN-α2, and anti–IFN-ω NAbs, respectively). Adjusted ORs with 95% CIs were calculated, and a P value <0.05 was considered statistically significant. (C–G) Age distribution of individuals in the all patients (C), NAb(+) (D), DSS NAb(−) (E), DHF NAb(−) (F), and DF NAb(−) (G)groups.