Figure 3.
Panel A shows a box plot comparing polygenic risk scores (PRS) based on 14 HLA-DQ genotypes between at-risk controls and celiac disease (CeD) cases. The y-axis represents PRS values, and the x-axis distinguishes between at-risk controls (n equals 117) and CeD cases (n equals 107). The median PRS for at-risk controls is 2.00, while for CeD cases it is 3.55. Panel B shows another box plot comparing PRS based on 14 HLA-DQ genotypes, HLA-B asterisk 08:01, and five additional non-HLA SNPs. The median PRS for at-risk controls is 2.32, and for CeD cases it is 4.03. Panel C is a table displaying the distribution of PRS quartiles in at-risk controls and CeD cases. The table includes columns for PRS quartiles, the number and percentage of at-risk controls and CeD cases in each quartile, odds ratios (OR) with 95 percent confidence intervals (CI), and p-values. The data shows an increasing trend in the percentage of CeD cases from the first to the fourth quartile, with corresponding increases in OR and significant p-values.
Genetic risk scoring for CeD risk stratification. (A) PRS based on 14 HLA-DQ genotypes. (B) PRS based on 14 HLA-DQ genotypes, HLA-B*08:01, and five additional non-HLA SNPs, difference between CeD cases and at-risk controls were evaluated using Student’s t test to compare mean values. (C) Distribution of PRS quartiles in the CeD and control groups.