Figure 1.
Panel A: A table summarizing the demographic characteristics of two study groups, At-Risk Controls (n equals 117) and CeD (n equals 107). The table has four rows and five columns. Column headers are Characteristics, At-Risk Controls (n equals 117), CeD (n equals 107), and P value. Row labels include Age (mean plus minus standard deviation), Female (n, percent), Genetic ancestry (n, percent), with subcategories European, Admixed American, South Asian, and African. Notable values include Age for At-Risk Controls being 33.62 plus minus 20.0 and for CeD being 21.9 plus minus 17.5, with a P value of less than 0.0001. Female percentage is 54.7 percent for At-Risk Controls and 69.2 percent for CeD, with a P value of 0.029. Genetic ancestry shows European as 85.5 percent for At-Risk Controls and 88.8 percent for CeD, Admixed American as 6.8 percent and 8.4 percent, South Asian as 6.0 percent and 2.8 percent, and African as 1.7 percent and 0 percent, with no significant difference noted. Panel B: A scatter plot showing genetic ancestry of participants compared with reference populations. The plot has Principal Component 1 on the x-axis and Principal Component 2 on the y-axis. Reference groups are color-coded as AFR (blue), AMR (orange), EAS (green), EUR (pink), and SAS (brown). Study groups are marked for At-risk controls and for CeD. The plot shows clustering of participants within these reference groups.
Characteristics and genetic ancestry of study participants. (A) Table summarizing the demographic characteristics of the two study groups. (B) Genetic ancestry of the participants compared with reference populations from the HapMap Project. AFR, African; AMR, Admixed American; EAS, East Asian; EUR, European; SAS, South Asian; N.S., not significant.