The diagram is divided into two main sections. The top section illustrates the role of NCoR binding and RARA-mediated repression in immortalization. It shows a complex formed by PML, RARA, GPS2, and NCoR, which leads to repression and a differentiation block. A mutation (I396E) disrupts this complex, allowing differentiation. The bottom section explains how PML::RARA partners sumoylated by PML-bound UBC9 drive repression. It depicts the interaction of GATA2, IRF2BP2, UBC9, PML, RARA, GPS2, NCoR, and SUMO2, leading to repression. The use of a SUMO inhibitor (TAK-981) disrupts this repression, allowing differentiation. The diagram highlights the importance of PML as a recurrent RARA fusion partner.