Panel A shows representative current traces and bar graphs of maximum current for Glu, AMPA, and Kai across the indicated AMPA receptor combinations. Panel B shows representative current traces and a bar graph of CNQX-induced modulation for Rat-GluA2 AMPA receptors alone or with TARP-gamma2. Panel C shows representative current traces and a bar graph of CNQX-, DNQX-, and NBQX-induced modulation for Sac-GluA AMPA receptors with TARP-XP_006822518 or TARP-XP 006816113. Panel D shows representative current traces and a bar graph of CNQX-induced modulation for Lin-g8707 plus Lin-g16613 AMPA receptors alone or with TARP g21034 or TARP g12410. Panel E shows representative current traces and bar graphs of CNQX-induced modulation for Hof-98007595 plus Hof-98019615 or Hof-98014323 AMPA receptors alone or with TARP 98036255.
AMPAR pharmacology. (A) Example (upper panels) and individual data points and means (dots and columns in lower panels) for indicated agonist-gated currents in oocytes expressing indicated AMPARs and TARPs from R. norvegicus (Rat, n = 4), S. kowalevskii (Sac, n = 5–7), L. anatina (Lin, n = 4), and H. miamia (Hof, n = 6). (B–E) Upper or left panels, example glutamate-gated current in absence and presence of indicated drugs. Lower or right panels, data points and means (dots and columns) of percentage of modulation of glutamate-gated current by CNQX, DNQX, and NBQX (n = 2–5 as shown). “−100% modulation” equates to complete inhibition. 100% modulation equates to doubling of current amplitude. Sac-TARP-XP…2518 and …6113 in A and C refer to TARP-XP_006822518.1 and XP_006816113.1.