Figure 1.
The diagram illustrates IL-6 family cytokine signaling pathways and the related IL-31 axis relevant to the genetic dissection of STAT3-HIES. IL-6, IL-11, LIF, and OSM signal through gp130/IL6ST-containing receptor complexes, whereas IL-31 signals through a distinct IL-31RA–OSMRβ receptor complex. OSM can signal through two receptor complexes: the type II OSM receptor, composed of OSMRβ and gp130/IL6ST, and the type I OSM receptor, composed of LIFR and gp130/IL6ST. Downstream activation of JAKs and STAT3 is shown, highlighting both the shared role of gp130/IL6ST in IL-6 family cytokine signaling and the gp130-independent IL-31RA–OSMRβ axis.
IL-6 family cytokine pathways involved in the genetic dissection of the STAT3-HIES phenotype.