Figure S3.
Panel A shows data for sham-infected mice treated with monoclonal antibodies (mAb) to IL1 beta or TNF alpha. The y-axis represents fold change, and the x-axis labels the groups: Sham, Sham plus alpha IL1 beta, and Sham plus TNF alpha. Each symbol represents an individual mouse, with bars indicating the mean and standard error of the mean (SEM). The data show no significant differences (ns) between the groups. Panel B shows data for Bb-infected mice treated with mAb to IL1 beta or TNF alpha. The y-axis represents fold change, and the x-axis labels the groups: Bb, Bb plus alpha IL1 beta, and Bb plus alpha TNF alpha. Each symbol represents an individual mouse, with bars indicating the mean and SEM. The data show no significant differences (ns) between the groups. The scatter plots indicate that neither IL-1 beta nor TNF alpha neutralization affects intestinal permeability during Bb infection.
Effect of IL-1β and TNF-α neutralization on intestinal permeability during Bb infection. (A and B) Data represent the fold change in serum FITC-dextran concentrations 4 h after gastric application at day 14 after infection compared with day 0 in (A) sham-infected and (B) Bb-infected mice treated with mAb to IL-1β or TNF-α. Bars indicate the mean ± SEM, and each symbol represents an individual mouse (n = 3/group in A; n = 8/group in B). Results in A are from one experiment; B shows pooled data from two independent experiments. Statistical analyses were done by one-way ANOVA; ns, not significant (P > 0.05).