Panel A shows boxplots of regression coefficients for CD36WT and CD36G12V MSS slope in the center region from MVRG analysis on speckle displacement and density. The x-axis is labeled Local Speckle with categories Displacement and Density, and the y-axis is labeled Regression coefficient for CD36WT MSS slope. Panel B shows similar boxplots for the periphery region. Panel C shows boxplots of regression coefficients for CD36WT and CD36G12V MSS slope in the center region from MVRG analysis on speckle displacement alone. The x-axis is labeled Local Speckle with the category Displacement, and the y-axis is labeled Regression coefficient for CD36WT MSS slope. Panel D shows similar boxplots for the periphery region. Panel E shows boxplots of regression coefficients for CD36WT and CD36G12V diffusion coefficient on speckle displacement and density. The x-axis is labeled Local Speckle with categories Displacement and Density, and the y-axis is labeled Regression coefficient for CD36WT diffusion coefficient. Panel F shows similar boxplots for diffusion radius. Panel G shows boxplots of regression coefficients for CD36WT and CD36G12V diffusion coefficient from MVRG analysis on speckle displacement alone. The x-axis is labeled Local Speckle with the category Displacement, and the y-axis is labeled Regression coefficient for CD36WT diffusion coefficient. Panel H shows similar boxplots for diffusion radius. Each panel includes data points, boxplots, and regression lines showing relationships between speckle displacement, density, and regression coefficients.
Regression coefficients from MVRG analysis on local CA speckle displacement and density, and from MVRG analysis on local CA speckle displacement alone. (A and B) Regression coefficients of CD36WT and CD36G12V MSS slope in the center (A) and periphery (B) regions from MVRG analysis on speckle displacement and density. This is the same MVRG analysis as in Fig. 2, A and B, but showing both regression coefficient components here (while Fig. 2, A and B show only the displacement component). (C and D) Regression coefficients of CD36WT and CD36G12V MSS slope in the center (C) and periphery (D) regions from MVRG analysis on speckle displacement alone. (E and F) Regression coefficients of CD36WT and CD36G12V diffusion coefficient (E) and diffusion radius (F) on speckle displacement and density. This is the same MVRG analysis as in Fig. 4, A and B, but showing both regression coefficient components here (while Fig. 4, A and B show only the displacement component). (G and H) Regression coefficients of CD36WT and CD36G12V diffusion coefficient (G) and diffusion radius (H) from MVRG analysis on speckle displacement alone. All figure details (including significance asterisks) are as in Fig. 2 and Fig. 4. Comparing A vs. C, and B vs. D, and E vs. G and F vs. H shows very similar regression coefficients on displacement whether MVRG is performed on displacement and density or displacement alone. At the same time, including the density in the MVRG analysis yields somewhat cleaner results for the displacement regression coefficients (e.g., the dense-periphery analysis in B vs. D). See Table 5 for the number of cells, the number of experimental repeats, and the number of SM tracklets and speckles per ROI used for analysis.