Figure 5.
Panel A shows laboratory-level TREC referral rates for NeoMDx, with the x-axis representing TREC referral rate in percent and the y-axis representing TREC cutoff value in copies per 10 superscript 6 cells. Panel B shows laboratory-level KREC referral rates for NeoMDx, with the x-axis representing KREC referral rate in percent and the y-axis representing KREC cutoff value in copies per 10 superscript 6 cells. Panel C shows laboratory-level TREC referral rates for NeoSMAART T/K/S, with the x-axis representing TREC referral rate in percent and the y-axis representing TREC cutoff value in copies per microliter. Panel D shows laboratory-level KREC referral rates for NeoSMAART T/K/S, with the x-axis representing KREC referral rate in percent and the y-axis representing KREC cutoff value in copies per microliter. Panel E is a table summarizing heterogeneity statistics (I squared and tau squared with 95 percent confidence intervals) for the assay kits. Each point in the forest plots represents individual laboratories, with point size reflecting the number of tests. Laboratories are ordered by laboratory-defined cutoff values.
Interlaboratory heterogeneity in TREC and KREC referral rates by the assay kit. (A–D) Laboratory-level referral rates with 95% CIs for kits used by at least five laboratories. Each point represents individual laboratories. The point size reflects the number of tests. Laboratories are ordered by laboratory-defined cutoff values. (E) Heterogeneity statistics (I2 and τ2 with 95% CIs). Values >0.40% are truncated.