Figure 4.
Panel A shows a bar and line graph with the number of TREC measurements on the left y-axis in units of measurements and TREC referral rates on the right y-axis in percent. The x-axis represents different TREC measurement assay kits labeled A to H. The bar graph indicates the number of measurements, while the line graph shows TREC referral rates with error bars. Panel B presents a similar bar and line graph for KREC measurements, with the number of KREC measurements on the left y-axis and KREC referral rates on the right y-axis. The x-axis also represents different KREC measurement assay kits labeled A to H. Panel C is a scatter plot showing laboratory-level TREC referral rates on the y-axis in percent and assay kits on the x-axis labeled A to H. Bubble size indicates the number of tests, with gray bubbles representing no repeat sampling. Panel D is a similar scatter plot for KREC referral rates. Dotted lines in Panels C and D show overall TREC and KREC referral rates, respectively. Values above 0.20 percent are truncated in Panels C and D.
Assay-specific referral rates and interlaboratory heterogeneity in TREC/KREC-based NBS. (A and B) Number of tests performed and TREC/KREC referral rates for each assay kit. Solid lines indicate assay kit–specific referral rates, and dotted lines indicate the overall TREC/KREC referral rates. P values were calculated using chi-square tests comparing referral rates across assay kits. (C and D) Laboratory-level referral rates, stratified by the assay kit. The bubble size represents the number of tests. Gray bubbles indicate no repeat sampling. Dotted lines show overall rates (TREC 0.04%, KREC 0.03%). Values >0.20% are truncated.