Figure S1.
The heat map is divided into three panels: one for patients under 18, one for pediatric-onset patients 18 and older, and one for adult-onset patients 18 and older. The x-axis represents initial clinical manifestations, including neither, infection only, immune dysregulation only, and both. The y-axis represents current age, ranging from 0 to 80. The color scale on the right indicates the odds of monogenic CVID, with red representing higher odds and blue representing lower odds. The highest predicted probabilities are observed among currently pediatric patients with neither infection nor immune dysregulation as the initial manifestation. The heat map shows a gradient of colors, with darker colors indicating lower odds and lighter colors indicating higher odds. The data is actual and derived from a regression model.
Heatmap illustrating regression model–derived predicted odds of monogenic CVID across current-age strata and presenting phenotype in ESID-R CVID patients. Panels distinguish currently pediatric patients, adults with pediatric-onset disease, and adults with adult-onset disease. The highest predicted probabilities were observed among currently pediatric patients with neither infection nor immune dysregulation as the initial manifestation (80.8–83.4%). Interactive HTML version of the heatmap is available at the following link: https://esid.org/html-pages/FigS1_Interactive_HeatMap_CurrentAge_Manifestations.html.