Figure 2.
The diagram is divided into several sections: Target, IgG subtype, Conjugation method, Linker type, and Payload. The Target section includes cancer cell surface proteins, post-translational modifications, secreted protein in the tumor microenvironThe diagram includes labeled parts such as antigen expression, internalization, microtubule disruption, DNA repair, cell cycle arrest, immune activation, and antibody-drug conjugate. The flow of the process is depicted with arrows indicating the sequence from antigen expression to cell death. The right side of the diagram lists combination partners and their roles in regulating surface targets, target internalization, DDR pathway inhibition, cell cycle control, cell death control, immune cell activation, and antibody-based therapy.
ADC combination therapies. Illustration highlighting seven categories of ADC combination therapies that are currently being developed. Copyright used with the permission of The Board of Regents of the University of Texas System through The University of Texas MD Anderson Cancer Center.