Figure 1.
The diagram is divided into several sections: Target, IgG subtype, Conjugation method, Linker type, and Payload. The Target section includes cancer cell surface proteins, post-translational modifications, secreted protein in the tumor microenvironment (TME), and surface proteins on TME cells. The IgG subtype section shows different immunoglobulin G subtypes: IgG1, IgG2, IgG3, and IgG4. The Conjugation method section depicts non-specific, specific/selective, and dual payload methods. The Linker type section includes cleavable and non-cleavable linkers, with cleavable linkers further divided into enzyme labile, pH labile, and redox labile. The Payload section includes anti-microtubule agents, immune activators, targeted drugs, DNA damage agents, radioligands, and degraders.
ADC design menu. Illustration highlighting the major components of ADC design used in currently approved and investigational ADCs: (1) target, (2) IgG subtype, (3) conjugation method, (4) linker, and (5) payload. Copyright used with the permission of The Board of Regents of the University of Texas System through The University of Texas MD Anderson Cancer Center.