A developing embryo, positioned laterally with the anterior to the left, is shown with labeled structures and processes. Blue dots depict early dividing nuclei. The germplasm (green) is located at the posterior pole. Torso receptor kinase is active at the anterior pole of the embryo and regions bordering the posterior pole. The inserts show regions with high and low levels of PIP3, indicating that PIP3 is low at the posterior pole, where the germplasm is located and high at the anterior pole and regions bordering the posterior pole, where Torso is active. Myosin 2 recruitment mediates a constriction (circular arrow) that pinchess off the pole bud from the rest of the emrbyo, leading to germ cell formation. The diagram also includes a flowchart at the bottom, showing the sequence of molecular interactions: GCL degrades Torso in the germplasm region. Torso activates Ras. RAS is known to activate the transcription of genes developing into the embryo's terminal structures in the purple areas (not shown). This study reveals that Torso can also activate PI3K, leading to the production of PIP3. High PIP3 levels suppress primordial germ cell fomation, explaining the need for GCL to degrade Torso to allow germ cells to form.