A scatter plot showing rare and common homozygous IL23R missense variants. The x-axis represents the minor allele frequency (MAF) from the gnomAD database, and the y-axis represents the CADD score. Different symbols indicate isomorphic, loss-of-function (LOF), and hypomorphic variants. A graph illustrating the effect of four hypomorphic IL23R alleles on STAT3 phosphorylation. The x-axis lists the alleles, and the y-axis shows the percentage of STAT3 phosphorylation. A map and a graph depicting the enrichment of homozygous hypomorphic IL23R variants in tuberculosis patients. The map highlights regions with significant enrichment, and the graph shows the odds ratio for the G300V variant. Panel D is an illustration explaining the impaired IFN-gamma production in cells with hypomorphic IL23R variants, showing the signaling pathway and the impact on immune cells.