Figure 1.
Panel A shows a molecular structure model of Nav1.4 channel highlighting pore, DIS6, N454, L458 residues. Panel B shows a molecular structure model providing enlarged cytoplasmic pore view and residue arrangement. Overall, molecular models illustrate channel pore architecture and positions of key pore-lining residues.
Human Nav1.4A. (A) (PDB model 6AGF). Side view, cytoplasmic side down. White spheres, 3-D depiction of atoms of molecules of DIS6 and part of the S5–S6 linker that form one quarter of the wall of the channel. The other three S6 segments and linkers that complete the channel are retained as sticks to allow the view of the location of N454 (orange spheres) of the sequence NEATL and of L458 (red spheres) of the same sequence. Blue spheres, eight residues, two from each S6 segment, form a double ring structure at the narrowest part of the pore at the cytoplasmic end. (B) Same model as shown in A, flipped upward and magnified to show a vertical view from the end of DIS6 and into the channel from the cytoplasmic side.