Figure S3.
Each graph represents a different diagnosis trigger: clinical illness, family history, and newborn screening. The x-axis represents time in years, and the y-axis represents the probability of OS. A graph shows a significant difference in OS between non-Hispanic White and non-Hispanic Black patients diagnosed by clinical illness, with the probability of OS being lower for non-Hispanic Black patients. The other graph shows no statistical difference in OS between the two groups when diagnosed by family history. Another graph also shows no statistical difference in OS between the two groups when diagnosed by newborn screen. The graphs use red lines to represent non-Hispanic White patients and teal lines to represent non-Hispanic Black patients.
Sensitivity analyses evaluating overall survival stratified by diagnosis trigger restricted to the contemporary era. (a) Diagnosed by clinical illness. (b) Diagnosed by family history. (c) Diagnosed by newborn screen. Red represents NH White patients, and teal represents NH Black patients. While there is a significant difference among those diagnosed by clinical illness (a, P = 0.003), there is no statistical difference among those diagnosed by FH (b) or NBS (c).