Figure 2.
Each graph shows the survival probability on the vertical axis and time in years on the horizontal axis. The graphs use different colors to represent non-Hispanic White (red), Hispanic (blue), and non-Hispanic Black (green) patients. A graph shows the survival probabilities for patients diagnosed with clinical illness. Non-Hispanic White patients have the highest survival probability, followed by Hispanic patients, and non-Hispanic Black patients have the lowest. The p-values indicate significant differences among the groups. The other graph shows the survival probabilities for patients diagnosed by family history. The survival probabilities are more similar among the groups, with no significant differences indicated by the p-values. Another graph shows the survival probabilities for patients diagnosed by newborn screening. The survival probabilities are also similar among the groups, with no significant differences indicated by the p-values. The graphs suggest that the introduction of newborn screening improved the five-year overall survival for all patients, particularly for non-Hispanic Black patients.
Overall survival by race and ethnicity stratified by diagnosis trigger. (a) Diagnosed by clinical illness. (b) Diagnosed by family history. (c) Diagnosed by newborn screen. Red represents NH White patients, blue represents Hispanic patients, and green represents NH Black patients. While there is a significant difference among those diagnosed by clinical illness (a, P = 0.022, P < 0.001, respectively), there is no statistical difference among those diagnosed by FH (b) or NBS (c).