Panel A shows scatter plots. The x-axes represent IFN-λ2/3 levels, and the y-axes represent alpha-SMA and fibronectin levels. Panel B presents scatter plots of Pearson correlation analysis. The x-axes represent Ifn-λ2/3 mRNA levels, and the y-axes represent Acta2, fibronectin, and vimentin mRNA levels. Panel C includes scatter plots of Pearson correlation analysis. The x-axes represent IFN-v2/3 levels, and the y-axes represent alpha-SMA, fibronectin, ACTA2, and FIBRONECTIN levels. Each plot shows individual data points pooled from two independent experiments, with correlation coefficients and p-values indicated.
Correlation between renal IFN-λ expression and renal fibrosis. (A) Pearson correlation analysis between IFN-λ2/3, α-SMA, and fibronectin relative mean OD (MOD) levels in kidneys from UUO mice at days 7 and 14 after surgery (n = 6). (B) Pearson correlation analysis of Ifn-λ2/3 mRNA levels with Acta2, fibronectin, and vimentin mRNA levels in kidneys from UUO mice at days 7 and 14 after surgery (n = 6). (C) Pearson correlation analysis of IFN-λ2/3, α-SMA, and fibronectin MOD values in kidney samples from CKD patients (n = 12) (left panel). Pearson correlation analysis of IFN-λ2/3 mRNA levels with ACTA2 and fibronectin mRNA levels in kidney samples from CKD patients (n = 12) (right panel). Data are represented as individual data points pooled from two independent experiments. The correlation coefficient and corresponding P values by the Pearson correlation test.