Figure S3.
Panel A shows scatter plots comparing normalized median fluorescence intensity of CCR2, CX3CR1, MHC-2, and CD206 in bone marrow-derived macrophages from control and Lxrab-/- mice, either untreated or exposed to apoptotic hepatocyte. Panel B shows scatter plot comparing Cd206 messenger RNA levels in controls and Lxrab-/- macrophages either untreated or exposed to apoptotic hepatocytes.
Lxrab-dependent regulation of Mφ phenotypical features. BMDMs from either WT or Lxrab−/− mice were left untreated (Untr) or treated for 45 min with apoptotic hepatocytes (aH). (A) After removal of the non-cleared aH, flow cytometry analysis on BMDMs was performed. Graphs reporting the normalized median fluorescence intensity (MFI) for CCR2, CX3CR1, MHC-II, and CD206 are shown. (B) mRNA level of Cd206 in BMDMs treated as in A are shown. n = 4; mean ± SEM, Mann–Whitney U test. *P < 0.05.