Figure 2.
Panel A, titled Vascular events, shows the fraction of patients experiencing various vascular events. The x-axis represents the percentage from 0 to 100 percent, and the y-axis lists different vascular events such as any finding, livedo, stroke, and others. Panel B, titled Immune dysregulation (including lymphoproliferation), displays the fraction of patients with immune dysregulation issues. The x-axis represents the percentage from 0 to 100 percent, and the y-axis lists conditions such as any finding, recurrent fever, arthritis or arthralgia, and others. Panel C, titled Infections, shows the fraction of patients with different types of infections. The x-axis represents the percentage from 0 to 100 percent, and the y-axis lists infection types such as any finding, upper respiratory tract infections, and others. Panel D, titled Immunephenotyping, depicts the fraction of patients with various immunephenotyping results. The x-axis represents the percentage from 0 to 100 percent, and the y-axis lists results such as any finding, hypogammaglobulinemia, low T cells, and others. Panel E, titled Hematology, shows the fraction of patients with different hematological findings. The x-axis represents the percentage from 0 to 100 percent, and the y-axis lists findings such as any finding, anemia, leukocytopenia, and others. Each bar graph provides a visual representation of the prevalence of specific conditions among the patients.
DADA2 clinical phenotypes and laboratory immune phenotypes are heterogeneous. (A–E) Clinical phenotypes given as fraction of a total of n = 48 patients. The upper bar shows the fraction of patients showing any of the clinical phenotypes displayed below. Immunophenotyping results annotated with an asterisk (*) were only reported for a subgroup of patients. Here, the fraction is calculated based on the number of patients for which a phenotyping result was reported.