Figure 7.
The diagram shows the vacuole and cytosol with various proteins and complexes interacting. In nutrient-rich conditions, Elo2/3, Nsg1, Nsg2, and Hmg1/2 are present, with Hmg2 being stabilized. Ypf1 is also present, suppressing NVJ partitioning. In glucose-starvation conditions, Vac8 and Nvj1 are stabilized, and Hmg1/2 are oligomelized and activated. Nsg1 and Nsg2 are involved in suppressing HMG-CoA reductase activity and altering membrane properties. Elo2/3 and Hmg1/2 are destabilized, while Nsg2 is stabilized. The diagram illustrates the interactions and changes in protein stability and activity under different nutrient conditions.
A model for GS-dependent NVJ remodeling. Schematic model of NVJ remodeling under GS conditions. Color differences in the nuclear ER (nER) indicate predicted changes in membrane properties.