Figure 2.
Panel A: A bar graph showing the distribution of exoplasmic tail lengths in single-pass and multi-pass proteins. The horizontal axis represents loop length in amino acids (aa) on a logarithmic scale, and the vertical axis represents the proportion (percent). The graph includes two data series: single-pass proteins in blue and multi-pass proteins in red. The single-pass proteins have a higher proportion of longer exoplasmic tails compared to multi-pass proteins. Panel B: A bar graph showing the distribution of cytoplasmic tail lengths in single-pass and multi-pass proteins. The horizontal axis represents loop length in amino acids (aa) on a logarithmic scale, and the vertical axis represents the proportion (percent). The graph includes two data series: single-pass proteins in blue and multi-pass proteins in red. The multi-pass proteins have a higher proportion of shorter cytoplasmic tails compared to single-pass proteins. Panel C: A bar graph showing the distribution of multi-pass inter-TMD loop lengths, categorized as outside and inside. The horizontal axis represents loop length in amino acids (aa) on a logarithmic scale, and the vertical axis represents the proportion (percent). The graph includes two data series: outside loops in green and inside loops in purple. The outside loops have a higher proportion of shorter lengths compared to inside loops.
Length distributions of membrane protein loops and tails. (A–C) Length distributions of exoplasmic tails (A), cytosolic tails (B), and inter-TMD loops (C) in the human membrane proteome. All panels use a logarithmic x axis displaying loop length in aa. Zero-length loops are included in the first bin.