The diagram shows a membrane protein topology viewer for SEC61A1 displaying predicted transmembrane organization and protein structural features. The upper panel includes summary statistics for membrane-associated protein categories and a search interface highlighting SEC61A1. The middle panel presents protein information including amino acid length, number of transmembrane domains, N-terminal and C-terminal orientation, and signal-peptide status together with the full amino acid sequence. The lower schematic diagram illustrates the membrane topology of SEC61A1 with ten transmembrane domains embedded within the membrane, extracellular and cytosolic loops, and orientation of the N- and C-termini toward the cytosol. A highlighted tooltip identifies transmembrane domain 6, including amino-acid position, sequence, and predicted free-energy value.
Topology viewer for the human membrane proteome. Screenshot of the topology viewer web interface, illustrated with SEC61A1 (UniProt P61619). The full protein sequence is displayed at top with the selected TMD highlighted in yellow. Hovering over any aa in the full sequence will highlight the corresponding segment in the topology diagram. The topology diagram depicts TMDs as red rectangles embedded in a gray membrane, with outside loops shown in gold and inside loops in blue; dashed lines indicate loops >100 aa. Hovering over any TMD, loop, tail, or SS displays a tooltip with their biophysical properties including ΔGapp, position, length, location, and sequence (illustrated here for TMD6: ΔGapp = −0.117, position 242–260, 19 aa). The protein is flagged as a common essential gene. Specific sequences or motifs can be identified via a search function. For example, glycosylation sequons can be searched as NX(ST) or N!P(ST), where X indicates any aa, and !P excludes Pro at the second position, and include both Ser and Thr at the third position. The viewer also supports SVG diagram download and feature table download.