Figure S1.
Curation of the human membrane proteome. Flowchart summarizing the curation process used to assemble the dataset of human ER-inserted membrane proteins. See text and methods for details. Refer to the image caption for details. The flowchart begins with all candidates totaling 5,548 from AFTM and UniProt. The first step removes 324 mitochondrial candidates identified by UniProt and MitoCarta 3.0, leaving 5,224 non-mitochondrial candidates. These candidates undergo a cross-database concordance check, resulting in 3,307 concordant and 1,917 conflicted candidates. The concordant candidates have 13 obsolete mito/cytosolic entries removed, contributing to the final curated dataset. The conflicted candidates have 348 entries removed, including 45 secreted, 10 hairpin, 290 non-TMD, and 3 obsolete entries. The final curated dataset comprises 4,863 entries.

Curation of the human membrane proteome. Flowchart summarizing the curation process used to assemble the dataset of human ER-inserted membrane proteins. See text and methods for details.

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