Figure 4.
OSMR variants lead to decreased OSMRβ cell surface expression in primary fibroblasts. (A) Extracellular and total OSMRβ expression were quantified in primary fibroblasts from P1, P2, and P3 (unable to obtain fibroblasts from P4 through P10) and three healthy controls using flow cytometry; n = 3. (B) Quantification of A, extracellular OSMRβ expression; n = 3. (C) Quantification of A, total OSMRβ expression; n = 3. Statistical comparisons based on unpaired t test. Asterisks denote P values: * < 0.05. FMO, fluorescence minus one. Refer to the image caption for details. Panel A shows two histograms comparing extracellular and total OSMR beta expression in primary fibroblasts from patients and healthy controls. The x-axis represents OSMR beta levels, while the y-axis represents the number of cells. The graphs show distinct peaks for each sample, with patients exhibiting lower peaks compared to healthy controls. Panel B is a bar graph quantifying extracellular OSMR beta expression. The x-axis labels are Patients and Healthy Controls, and the y-axis shows MFI fold change relative to FMO. Patients have lower bars compared to healthy controls, indicating decreased expression. Panel C is another bar graph quantifying total OSMR beta expression, with similar axes and trends as Panel B.

OSMR variants lead to decreased OSMRβ cell surface expression in primary fibroblasts. (A) Extracellular and total OSMRβ expression were quantified in primary fibroblasts from P1, P2, and P3 (unable to obtain fibroblasts from P4 through P10) and three healthy controls using flow cytometry; n = 3. (B) Quantification of A, extracellular OSMRβ expression; n = 3. (C) Quantification of A, total OSMRβ expression; n = 3. Statistical comparisons based on unpaired t test. Asterisks denote P values: * < 0.05. FMO, fluorescence minus one.

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