Figure 2.
The centriolar cap section includes proteins such as CLASP, Klp10A, KIF24, CPAP, CP110, and CEP97. The ciliary tip section includes proteins such as CEP104, EB, CCDC66, ARMC9, CSPP1, TOGARAM1, KIF19A, and KIF7. The diagram shows protein-protein interactions with dashed lines, negative regulation of growth with red lines, and tubulin addition to paused end with green arrows. GTP-Tubulin and GDP-Tubulin are represented by different colored circles.
Interactions of the centriolar cap and the ciliary tip proteins. Scheme of protein–protein interactions and plus-end growth regulation in the centriolar cap and the ciliary tip. The scheme comprises the following proteins: Orbit/Mast/CLASP, KIF24, Klp10A of the kinesin-13 family, CPAP, CP110, CEP97, CCDC66, CEP104, EB3, ARMC9, CSPP1, TOGARAM1, KIF7, and KIF19A. CLASP, cytoplasmic linker–associated protein; KIF24, kinesin family member 24; Klp10A, kinesin-like protein at 10A; CP110, centriolar protein of 110 kDa; CEP97, centrosomal protein 97; CEP104, centrosomal protein 104; EB3, end-binding protein 3; TOGARAM1, TOG array regulator of axonemal microtubules 1; KIF7, kinesin family member 7; KIF19A, kinesin family member 19A.