Figure 2.
Panel A contains three line graphs showing serum immunoglobulin levels (IgG, IgM, and IgA) over time. The x-axis represents years, and the y-axis represents levels in mg/dL. Panel B contains three line graphs showing T-cell, B-cell, and NK-cell counts over time. The x-axis represents years, and the y-axis represents cell counts in cells/microliter. Panel C contains six line graphs showing counts of different B-cell subsets (naïve B cells, transitional B cells, unswitched memory B cells, CD21lo B cells, switched memory B cells, and plasmablasts) over time. The x-axis represents years, and the y-axis represents cell counts in cells/µL. Grey-blue shaded areas indicate age-matched normal ranges, with values outside considered abnormal.
Serum immunoglobulin levels and lymphocyte subset counts in eight patients with CHAPLE disease. (A) Serum immunoglobulin levels. (B) T, B, and NK cell counts. (C) B cell subset counts. Grey-blue shaded areas indicate age-matched normal ranges, with values outside considered abnormal (12, 13).