Figure 7.
The flowchart illustrating the decision algorithm for determining the use of immune suppression in infants with congenital athymia and criteria for weaning immune suppression post-implantation. The flowchart starts with congenital athymia with naïve T cells less than 50 cells per cubic millimeter. It then branches into two paths based on PHA levels. If PHA is less than 10 percent of the lower limit of normal and CD3 T cells are less than 100 cells per cubic millimeter with no autoimmunity, no immune suppression is required. If PHA is greater than 10 percent of the lower limit of normal or CD3 T cells are greater than 100 cells per cubic millimeter or there is autoimmunity, ATG is administered prior to CTTI with or without a calcineurin inhibitor. Immune suppression is weaned when CD3 is greater than 200 cells per cubic millimeter and naïve T cells are greater than 10 percent of total CD3 T cells.
Immune suppression protocol. Proposed decision algorithm for determining use of immune suppression in infants with CA and criteria for weaning immune suppression after implantation. ATG, antithymocyte globulin.